Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
J. Clin. Invest. Jessie R. Zhang, et al. 118:2281 doi:10.1172/JCI32561 [Go to this article.]

Figure 2
Serum lipoprotein cholesterol and TG levels in MϕNpc1^+/+ and MϕNpc1^–/– mice fed an atherogenic diet. (A) Quantitative lipoprotein analysis of serum lipoproteins. Sera from 9–10 animals per genotype fed the high-fat diet for 0, 3, 6, and 10 weeks were pooled and analyzed by HPLC. Data are mean ± SEM. *P ≤ 0.05, **P ≤ 0.005 versus MϕNpc1^+/+. (B) FPLC profile of cholesterol and TGs in mice fed the high-fat diet for 10 weeks. Sera from 5–6 animals per genotype were pooled and separated by FPLC, and individual fractions were assayed for cholesterol and TG content. Data represent means of triplicate determinations for each genotype. SEM and statistical analyses are shown in Table 1.